The research program of the FrontINove IRN is evolutive and will adapt to novel challenges emerging in the field of Immunology. Novel axis or areas of interest will be discussed among partners of the project to define new infra- or extra-network collaborations to support.
Nadine Laguette
Nadine Laguette, Molecular Basis of Inflammation lab, Institute of Human Genetics, CNRS UMR9002, Montpellier, FRANCE
Christelle Langevin
Christelle Langevin, Experimental Infectiology Unit for rodents and fish – Université Paris-Saclay, INRAE UE 0907, 78350, Jouy-en-Josas, France
Nicolas Bidere
Nicolas Bidere, SOAP – Signaling in Oncogenesis, Angiogenesis, and Permeability
Andrew Jackson
Andrew Jackson : Jackson Research Group, MRC Human Genetics Unit, UK
François Treussart
Soren R. Paludan
Soren R. Paludan : Paludan Lab, Department of Biomedicine, Aarhus University, DK
Dimitrios Vlachakis
Dimitrios Vlachakis : Genetics Laboratory, Biotechnology Department, School of Applied Biology and Biotechnology, Agricultural University of Athens.
Petr Cigler
Petr Cigler : Synthetic Nanochemistry, Head. Institute of Organic Chemistry and Biochemistry of the CAS Prague, Czech Republic
Philippe Pourquier
Philippe Pourquier : Gongora Lab, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Montpellier Cedex, France
Ivan Huc
Ivan Huc : Biomimetic Supramolecular Chemistry – Department of Pharmacy, Ludwig-Maximilians-Universität Munich – Germany
Barbara Nawrot
Barbara Nawrot : Centre of Molecular and Macromolecular Studies PAS
Martin Cohen-Gonsaud
Martin Cohen-Gonsaud : Gonsaud Lab, Centre de Biochimie Structurale (UMR 5048 CNRS – INSERM) Université de Montpellier)
Nadine Laguette, Molecular Basis of Inflammation lab, Institute of Human Genetics, CNRS UMR9002, Montpellier, FRANCE
Nadine Laguette studied molecular biology and genetics at the Royal Holloway college of the University of London (UK). She received her PhD in cell biology from the University of Paris V in 2008. In 2009 she joined the Institute of Human Genetics (IGH) in Montpellier initially as a postdoctoral fellow where she worked on virus-host interactions. After securing a CNRS permanent position in 2012, she moved her research towards innate immunity. Since 2015, she heads a research group within the IGH that takes interest in uncovering the molecular mechanisms underlying pathological inflammation. She is the recipeint of several prestigious awards and grants, including an ERC-Starting Grant and an ERC-Proof-of-concept Grant. She coordinates the FrontINov Network together with Petr Cigler.
Christelle Langevin
Christelle Langevin, Experimental Infectiology Unit for rodents and fish – Université Paris-Saclay, INRAE UE 0907, 78350, Jouy-en-Josas, France
Christelle Langevin studied microbiology at the University Paris XI, and received her PhD in Virology in 2003. From 2003 to 2010, she worked at Institute for research on agriculture, food, and the environnent (INRAE) and Pasteur Institute as a Post-doc on prion diseases. Since 2010, as INRAE researcher, she leads projecst on host – pathogen interactions. Using zebrafish larvae as a biomedical model, she contributes to study the virulence of diverse pathogens and host responses focused on activation and regulation of interferon pathway. Since 2012, she is the scientific manager of a zebrafish phenotyping platform, which aims to provide services to the scientific community through (1) producing in vivo models for the study of infectiology and immunity and (2) screening therapeutic molecules targeting animal or human health diseases. Recent R&D activities focussed on novel tools for in vivo visualization of nucleic acid immunity combining zebrafish imaging and nanotechnology.
Nicolas Bidere, SOAP – Signaling in Oncogenesis, Angiogenesis, and Permeability
Nicolas Bidère obtained a PhD from University Paris 11 in 2004. He then joined the Laboratory of Immunology at the NIH as a post-doctoral fellow, where he grew interest in the molecular basis for NF-kB activation. In 2008, he was appointed permanent researcher by INSERM and is now conducting his researches at the Research Center in Cancerology and Immunology Nantes-Angers (CRCINA). He has a long-term experience in exploring life-and-death decisions in normal and pathological conditions, with a large emphasis on NF-κB signaling and reversible ubiquitination.
Prof. F. Treussart (FT) leads the “Biophotonics and Physiopathologies of Synapses” team at Laboratoire “Lumière, Matière et Interfaces” (CNRS, ENS Paris-Saclay, Univ. Paris-Saclay, CentraleSupélec, France). FT studied Physics and Chemistry at ENS and specialized in quantum optics and lasers. Following a PhD at the Kastler Brossel Laboratory (Paris), he was recruited as an assistant professor at ENS Paris-Saclay in 1998 where he developed an expertise in the spectroscopy of single emitters and nanocrystals. In 2006 FT was promoted Professor and initiated the applications of fluorescent nanodiamonds (FND) to bio-imaging in collaboration with Huan-Cheng Chang (Taiwan). Recently, in collaboration with Michel Simonneau (Prof. Emeritus, Dept of Biology, ENS Paris-Saclay), FT invented a technique based on tracking single FND in neuronal branches to reveal slight abnormalities in intraneuronal transport linked to neuropsychiatric disorders. He is now extending this approach to human brain organoids and to small animal in vivo (zebrafish larvae).
Soren R. Paludan : Paludan Lab, Department of Biomedicine, Aarhus University, DK
Søren R Paludan received his PhD in virology and Immunology from Aarhus University, Denmark in year 2000 after training in the UK, USA, and Denmark. He is now professor at Aarhus University, and guest professor at Gothenborg University, Sweden. The aim of his research is to understand how the innate immune system detects danger and translates this into protective and pathological immune responses. For this purpose he uses a broad range of experimental set-ups ranging from advanced cellular/molecular systems to animal models. He is recipient of several prestigious grants and awards, including an ERC Advanced Grant.
Soren R. Paludan : Paludan Lab, Department of Biomedicine, Aarhus University, DK
Dimitrios Vlachakis
Dimitrios Vlachakis : Genetics Laboratory, Biotechnology Department, School of Applied Biology and Biotechnology, Agricultural University of Athens.
Dimitrios Vlachakis leads the Dark DNA group at the Genetics Laboratory at the Biotechnology Department, School of Applied Biology and Biotechnology of the Agr. University of Athens. He is a medical biochemist with postgraduate, doctoral and postdoctoral studies in the eminent fields of genetics, epigenetics, evo-devo, gwas, medicinal chemistry, pharmacophore elucidation and drug discovery. His PhD and PostDocs in the USA & the UK led to a series of publications and an international patent on antiviral drugs. Since 2012 Dr. Vlachakis has been serving as the Editor in Chief of the Journal of Molecular Biochemistry and as the deputy editor in chief for EMBnet journal. He was recently elected as an Executive Board member the European Molecular Biology network. To date, he has published more than 140 original peer-reviewed articles, 8 books, 3 scientific patents and has been on the receiving end of numerous grants and awards.
Dimitrios Vlachakis : Genetics Laboratory, Biotechnology Department, School of Applied Biology and Biotechnology, Agricultural University of Athens.
Petr Cigler
Petr Cigler : Synthetic Nanochemistry, Head. Institute of Organic Chemistry and Biochemistry of the CAS Prague, Czech Republic
Petr Cígler received his PhD at UCT Prague (2008), afterwards he did his postdoc at The Scripps Research Institute, La Jolla, USA. Since 2013 he has been the head of the Synthetic Nanochemistry research group at the Institute of organic chemistry and biochemistry of the CAS, Prague. His current research interests include nanoparticles surface chemistry, their biointerface, and their applications in biomedicine and sensors. He published more than 70 peer-reviewed papers, H-index 26 (WoS). Web: nano.petrcigler.cz. Petr coordinates the network together with Nadine Laguette.
Petr Cigler : Synthetic Nanochemistry, Head. Institute of Organic Chemistry and Biochemistry of the CAS Prague, Czech Republic
Philippe Pourquier
Philippe Pourquier : Gongora Lab, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Montpellier Cedex, France
Philippe Pourquier obtained his Pharmacy degree from the University of Bordeaux (France) in 1992. Following a PhD in Biochemistry and Molecular Biology (1996) and a postdoctoral stay in the laboratory of Molecular Pharmacology at the National Cancer Institute (USA), he acquired a solid experience in the field of drug resistance to chemotherapies, in particular DNA topoisomerases inhibitors. In 2001 he obtained a senior investigator position at INSERM and was the head of the molecular pharmacology group of the INSERM U916 unit at the Bordeaux Cancer Institute, France. In 2013 he moved to the Montpellier Cancer Research Institute at INSERM U1194 where he is developing basic and translational research programs studying resistance mechanisms to drugs that are used in the treatment of colon and castration-resistant prostate cancers. These projects are developed in close collaboration with Nimes University Hospital with the aim to identify new strategies to overcome these resistance mechanisms. He has published more than 70 papers in peer-reviewed international journals including Nature Medicine and Nature Chemistry. Philippe Pourquier is the president of the scientific Council of the Regional League against Cancer and is a member of the Montpellier Faculty of Medicine.
Philippe Pourquier : Gongora Lab, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Montpellier Cedex, France
Ivan Huc
Ivan Huc : Biomimetic Supramolecular Chemistry – Department of Pharmacy, Ludwig-Maximilians-Universität Munich – Germany
Prof. Ivan Huc studied chemistry at the Ecole Normale Supérieure (ENS, Paris), and received his PhD in 1994 from the University of Paris VI for work done both at ENS and MIT (USA). From 1995, he worked at the University of Strasbourg as a Post-doc, then as a CNRS researcher. In 1998, he moved to the European Institute of Chemistry and Biology at the University of Bordeaux as a CNRS research director. Since 2017, he has been a Professor of Chemical Biology at the Department of Pharmacy of the University of Munich (LMU, Germany). His research focuses on foldamers, their use as pharmacological tools, and more generally biomimetic supramolecular chemistry.
Barbara Nawrot : Centre of Molecular and Macromolecular Studies PAS
Professor Barbara Nawrot is a Principal Coordinator of Bioorganic Chemistry Department in the Centre of Molecular and Macromolecular Studies (Lodz, Poland), which is an institute of the Polish Academy of Sciences. She herself leads two units – Laboratory of Nucleic Acid Therapeutics and Anticancer Compounds Screening Laboratory. She obtained a PhD degree in organic chemistry at the Lodz University of Technology. Her post-doctoral training in Memorial Sloan Kettering Cancer Center (New York, USA), followed by intensive and fruitful work as a visiting researcher in the Department of Biochemistry at Bayreuth University (Germany) and therapeutic nucleic acids – related research at Gene Discovery Research Center, AIST (Tsukuba, Japan), shaped her scientific interest in the field of medicinal chemistry, especially chemistry and biology of nucleic acids. She is an expert in rare modifications of nucleic acids and their components, with strong involvement in research on interaction of modified models with biomolecules. The most frequent keywords characteristic for her publication over last 15 years have been: gene expression inhibitors (antisense oligonucleotides, DNA- and RNA-zymes, nanostructures of DNA with boron clusters), modified nucleosides in tRNA function, HIT proteins and their nucleotide inhibitors, anticancer compounds.
Martin Cohen-Gonsaud : Gonsaud Lab, Centre de Biochimie Structurale (UMR 5048 CNRS – INSERM) Université de Montpellier)
Martin Cohen-Gonsaud is a researcher at the CBS of Montpellier working on structural biology and synthetic biology. His group is focused on Mycobacterium tuberculosis research and has solved many Mtb protein structures mainly using NMR but also X-ray crystallography and EM. The current projects are in link with the host-pathogen interaction, immunometabolism and inflammation.
Martin Cohen-Gonsaud : Gonsaud Lab, Centre de Biochimie Structurale (UMR 5048 CNRS – INSERM) Université de Montpellier)
Jean-Rémi BERTRAND, PhD, is Research Engineer (INSERM) in METSY UMR 9018 of the CNRS at Gustave Roussy institute. He received her PhD in molecular biology from the University of Paris VII in 1991. He was working since 1986 on gene inhibition by short nucleic acids such as antisense oligonucleotide and siRNA and developed strategies for their nanoparticles delivery in cells models and in vivo. For the last years, he has developed nanodiamonds strategy to deliver siRNA in Ewing sarcomas models and study in vivo their efficiency, bio-distribution and elimination pathways. Jean-Rémi Bertrand has published 70 peer review articles in international journals, 2 patents and 2 book chapters
Nadine LaguetteNadine Laguette, Molecular Basis of Inflammation lab, Institute of Human Genetics, CNRS UMR9002, Montpellier, FRANCE
Christelle LangevinChristelle Langevin, Experimental Infectiology Unit for rodents and fish – Université Paris-Saclay, INRAE UE 0907, 78350, Jouy-en-Josas, France
Nicolas BidereNicolas Bidere, SOAP – Signaling in Oncogenesis, Angiogenesis, and Permeability
Andrew JacksonAndrew Jackson : Jackson Research Group, MRC Human Genetics Unit, UK
François Treussart
Soren R. PaludanSoren R. Paludan : Paludan Lab, Department of Biomedicine, Aarhus University, DK
Dimitrios VlachakisDimitrios Vlachakis : Genetics Laboratory, Biotechnology Department, School of Applied Biology and Biotechnology, Agricultural University of Athens.
Petr CiglerPetr Cigler : Synthetic Nanochemistry, Head. Institute of Organic Chemistry and Biochemistry of the CAS Prague, Czech Republic
Philippe PourquierPhilippe Pourquier : Gongora Lab, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Montpellier Cedex, France
Ivan HucIvan Huc : Biomimetic Supramolecular Chemistry – Department of Pharmacy, Ludwig-Maximilians-Universität Munich – Germany
Barbara NawrotBarbara Nawrot : Centre of Molecular and Macromolecular Studies PAS
Martin Cohen-GonsaudMartin Cohen-Gonsaud : Gonsaud Lab, Centre de Biochimie Structurale (UMR 5048 CNRS – INSERM) Université de Montpellier)
Jean-Rémi BertrandJean-Rémi Bertrand, METSY (UMR 9018 – CNRS – Institut Gustave Roussy – Université Paris-Saclay)