Publications & achievements

A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology

ISD Immunotech Announces the publication of Soren’s Lab in EBioMedicine entitled “A STING antagonist modulating the interaction with STIM1

blocks ER-to-Golgi trafficking and inhibits lupus pathology”, Supporting Therapeutic Potential of its Lead Candidate ISD017 in Severe Lupus Patients. The paper describes ISD017, a selective peptide inhibitor of stimulator of interferon genes (STING), tha

t prevents all downstream activities of STING and disease in several mouse models of lupus. The drug candidate also prevents pathological inflammatory immune response in lupus patient blood samples. Thus, the results support the clinical benefit of ISD017 and its potential as a treatment for severe lupus.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047499/

The CNRS bronze medal was awarded to Nadine Laguette in 2021

and rewards the first works consecrating researchers specializing in their field. This distinction represents an encouragement from the CNRS to pursue well-initiated and already fruitful research.

http://ightest.igh.cnrs.fr/fr/sciences-et-societe/medaille-de-bronze-du-cnrs-2021

Biophysicists honored with Taiwan-France scientific prize

Biophysicists honored with Taiwan-France scientific prize 21st Franco-Taiwanese scientific grand prize was awarded jointly on November 27, 2019 in Paris to François Treussart and Chang Huan-cheng for their research, at the frontier of physics, chemistry and biology, on the use of fluorescent diamond nanocrystals in neuronal imaging. Awarded by the Taiwanese Ministry of Science and Technology and the Academy of Sciences in France, this prize rewards and encourages a Franco-Taiwanese scientific duo for their scientific contribution in a field of interest to both countries.

https://taiwantoday.tw/news.php?unit=10&post=166897

Nucleic Acid Immunity and DNA Damage Response: New Friends and Old Foes.

Frontiers in Immunology: https://doi.org/10.3389/fimmu.2021.660560

Taffoni C, Steer A, Marines J, Chamma H, Vila IK and Laguette N. 2021.

Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase (cGAS), a Multifaceted Platform of Intracellular DNA Sensing.

Verrier ER, Langevin C. Front Immunol. 2021 Feb 23;12:637399. doi: 10.3389/fimmu.2021.637399. eCollection 2021. PMID: 33708225 Free PMC article. Review

Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation.

Guerra J, Valadao AL, Vlachakis D, Polak K, Vila IK, Taffoni C, Prabakaran T, Marriott AS, Kaczmarek R, Houel A, Auzemery B, Déjardin S, Boudinot P, Nawrot B, Jones NJ, Paludan SR, Kossida S, Langevin C, Laguette N. Sci Adv. 2020 May 22;6(21):eaax3333. doi: 10.1126/sciadv.aax3333. eCollection 2020 May. PMID: 32494729

Animal Models for the Study of Nucleic Acid Immunity: Novel Tools and New Perspectives.

Vila IK, Fretaud M, Vlachakis D, Laguette N, Langevin C. J Mol Biol. 2020 Aug 26;S0022-2836(20)30510-6. doi: 10.1016/j.jmb.2020.08.016

New look at RSV infection : tissue clearing and 3D imaging of the entire mouse lung at cellular resolution

Maxence Frétaud, Delphyne Descamps, Daphné Laubreton, Marie-Anne Rameix-Welti, Jean-François Eléouët, Thibaut Larcher, Marie Galloux, Christelle Langevin. doi: https://doi.org/10.1101/2020.12.23.424099

Control of polyunsaturated fatty acids desaturation by Sting regulates inflammatory responses

Isabelle K. Vila, Hanane Chamma, Alizée Steer, Clara Taffoni, Line S. Reinert, Evgenia Turtoi, Mathilde Saccas, Johanna Marines, Lei Jin, Xavier Bonnefont, Soren R. Paludan, Dimitrios Vlachakis, Andrei Turtoi, Nadine Laguette. bioRxiv 2020.12.22.423950; doi: https://doi.org/10.1101/2020.12.22.423950